"Phagocytosis, recognition"

Across TCGA patient cohorts, RNA activity of the "Phagocytosis, recognition" pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C3, CFP, and PROS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Phagocytosis, recognition" activity versus C3 in OV (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C3 →	+0.444	+0.194	<.001	<.001	3	6
OV	CFP →	+0.780	+0.197	.001	.009	2	7
OV	PROS1 →	+0.694	+0.272	<.001	<.001	3	6
COAD	SERPINA3 →	+0.600	+0.284	.001	.001	3	5
OV	SERPINA6 →	+0.514	+0.169	<.001	<.001	3	5
COAD	C6 →	+0.821	+0.304	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006910 vs C3 — OV

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