"Phagocytosis, recognition"

Across TCGA cell cohorts, RNA activity of the "Phagocytosis, recognition" pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDIT4, PDCD4, and ZNF711, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDIT4 grouped by "Phagocytosis, recognition"-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DDIT4 →	-2.265	-1.250	.001	<.001	3	5
KIDNEY	PDCD4 →	+1.319	+1.017	.009	.009	3	4
LUNG_NSCLC_LUAD	ZNF711 →	+1.041	+0.919	.009	.001	3	4
STOMACH	PIH1D2 →	+0.669	+1.166	.002	.002	3	3
CNS	VEPH1 →	-1.718	-0.781	.008	.001	2	4
BLOOD_Myeloma	GOLGA4 →	+1.073	+1.648	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDIT4 by "Phagocytosis, recognition" activity — OVARY

Explore this box plot interactively →