"Phagocytosis, recognition"

Across TCGA cell cohorts, RNA activity of the "Phagocytosis, recognition" pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYNCRIP, CENPU, and PHF14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SYNCRIP grouped by "Phagocytosis, recognition"-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SYNCRIP →	+0.242	+0.276	<.001	.002	3	4
LUNG_NSCLC_LUAD	CENPU →	+0.135	+0.872	.001	.007	3	4
OESOPHAGUS	PHF14 →	-0.106	-0.483	.001	<.001	3	3
LUNG_SCLC	CFHR4 →	+0.230	+0.962	.006	.004	3	3
BLOOD_Leukemia	GRK2 →	+0.177	+0.291	.009	.001	3	3
BLOOD_Leukemia	CEBPA →	-0.345	-0.260	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SYNCRIP by "Phagocytosis, recognition" activity — URINARY_TRACT

Explore this box plot interactively →