Zinc ion transport

Across TCGA patient cohorts, RNA activity of the Zinc ion transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCEL, ZFP69B, and CRYM-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Zinc ion transport activity versus SCEL in PDAC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SCEL →	-0.840	-0.521	.009	.008	3	3
PDAC	ZFP69B →	-0.231	-0.659	.002	<.001	3	3
PDAC	CRYM-AS1 →	-0.327	-0.727	.002	.009	3	3
PDAC	OR7E13P →	-0.390	-0.842	.006	<.001	3	3
PDAC	RNU7-80P →	-0.357	-0.513	.003	.009	3	3
PDAC	RNU6-977P →	-0.571	-0.654	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006829 vs SCEL — PDAC

Explore this scatter interactively →