Cholesterol catabolic process

Across TCGA patient cohorts, RNA activity of the Cholesterol catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP27A1, SCARB1, and LYL1, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cholesterol catabolic process activity versus CYP27A1 in ACC (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	CYP27A1 →	+2.107	+0.055	<.001	.001	3	27
SKCM	SCARB1 →	+1.752	+0.117	<.001	<.001	3	27
SCLC	LYL1 →	+1.001	+0.254	<.001	<.001	2	24
SCLC	DOK2 →	+1.732	+0.266	<.001	<.001	3	23
SCLC	LST1 →	+1.652	+0.174	<.001	.002	3	23
SCLC	ABI3 →	+1.540	+0.167	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006707 vs CYP27A1 — ACC

Explore this scatter interactively →