Cholesterol catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Cholesterol catabolic process pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Cholesterol catabolic process pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCEC and BRCA, show the opposite pattern, with higher activity associated with better survival.

UVM, STAD, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	II,III,IV	0.341	0.766	<.001	142	view →
STAD	OS	Tertile	All	0.314	0.680	<.001	82	view →
UCEC	DFS	Median	All	0.756	0.550	.010	36	view →
THYM	DFS	Median	All	0.748	0.954	<.001	32	view →
BRCA	DFS	Quartile	II,III,IV	0.705	0.405	.003	30	view →
SKCM	OS	Median	All	0.266	0.387	.001	25	view →
HNSC	DFS	Quartile	III,IV	0.455	0.242	.006	22	view →
OV	DFS	Quartile	All	0.439	0.323	.008	18	view →
THCA	OS	Tertile	All	1.000	0.904	.005	18	view →
PRAD	DFS	Tertile	All	0.906	0.771	<.001	16	view →
CHOL	DFS	Tertile	All	0.113	0.656	.004	15	view →
READ	DFS	Quartile	All	0.849	0.470	.023	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0006707–UVM (OS)

Open the UVM breakdown →