Steroid catabolic process

Across TCGA patient cohorts, RNA activity of the Steroid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK8, HCK, and MYO1F, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Steroid catabolic process activity versus DOCK8 in LSCC (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DOCK8 →	+0.445	+0.067	<.001	<.001	3	9
BRCA	HCK →	+0.558	+0.055	<.001	<.001	3	9
UCEC	MYO1F →	+0.608	+0.079	<.001	.001	3	9
UCEC	CYP27A1 →	+0.529	+0.069	.001	.001	3	8
UCEC	VAV1 →	+0.566	+0.074	<.001	.002	3	8
UCEC	WAS →	+0.667	+0.086	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006706 vs DOCK8 — LSCC

Explore this scatter interactively →