Steroid catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Steroid catabolic process pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 25 member genes.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher Steroid catabolic process pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LIHC and CESC, show the opposite pattern, with higher activity associated with better survival.

LIHC, LUSC, and CESC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.737	0.441	.001	67	view →
LUSC	OS	Tertile	All	0.609	0.729	.006	40	view →
CESC	DFS	Median	All	0.643	0.429	.003	32	view →
GBM	OS	Quartile	All	0.298	0.514	.001	30	view →
THYM	DFS	Quartile	All	0.758	1.000	.001	27	view →
HNSC	DFS	Tertile	IV	0.542	0.327	.008	24	view →
BRCA	OS	Tertile	III,IV	0.850	0.955	.012	15	view →
LUAD	OS	Quartile	II,III,IV	0.878	0.636	.002	14	view →
STAD	DFS	Median	IV	0.138	0.500	.028	12	view →
DLBC	DFS	Tertile	III,IV	1.000	0.212	.023	10	view →
CHOL	DFS	Tertile	II,III,IV	0.155	0.664	.026	10	view →
ESCA	DFS	Tertile	All	0.534	0.270	.025	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0006706–LIHC (OS)

Open the LIHC breakdown →