Protein deglycosylation

Across TCGA patient cohorts, RNA activity of the Protein deglycosylation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HAAO, SEPTIN1_S315, and SLC38A2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein deglycosylation activity versus HAAO in LUAD (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HAAO →	+0.386	+0.053	<.001	<.001	3	7
GBM	SEPTIN1_S315 →	+1.388	+0.108	<.001	<.001	3	6
UCEC	SLC38A2 →	-0.722	-0.079	.001	.001	3	6
BRCA	ADD3_S650 →	+0.926	+0.071	<.001	<.001	3	6
GBM	GRAP2 →	+0.706	+0.096	.001	<.001	3	6
LUAD	ANK2_S890 →	+0.437	+0.029	.005	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006517 vs HAAO — LUAD

Explore this scatter interactively →