Regulation of gluconeogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of gluconeogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH1A1_S413, RPL5, and ANKRD17, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gluconeogenesis activity versus ALDH1A1_S413 in GBM (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ALDH1A1_S413 →	+0.697	+0.040	<.001	.003	3	5
BRCA	RPL5 →	-0.138	-0.022	.003	.001	3	5
BRCA	ANKRD17 →	-0.168	-0.018	.002	.008	3	5
CCRCC	SRRM2_S456 →	-0.896	-0.045	<.001	<.001	3	5
UCEC	RHBDF2_S385 →	-0.782	-0.070	.003	<.001	3	4
HNSC	USP24_S2330 →	-0.244	-0.040	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006111 vs ALDH1A1_S413 — GBM

Explore this scatter interactively →