Regulation of gluconeogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of gluconeogenesis pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as COAD and KICH, show the opposite pattern, with lower activity in tumor tissue.

COAD, KICH, and LUAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	All	IV	−0.051	<.001	11	view →
KICH	Female	II,III,IV	−0.074	<.001	10	view →
LUAD	Female	All	+0.039	<.001	8	view →
BLCA	Female	III,IV	+0.038	.011	6	view →
BRCA	All	All	−0.034	<.001	6	view →
LUSC	Male	All	+0.029	<.001	6	view →
KIRC	Male	All	+0.018	<.001	4	view →
THCA	All	All	−0.013	.004	4	view →
READ	All	All	−0.054	.001	3	view →
PRAD	All	All	+0.021	<.001	2	view →
HNSC	All	All	+0.015	.032	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0006111–COAD

Open the COAD breakdown →