Regulation of gluconeogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of gluconeogenesis pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 53 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Regulation of gluconeogenesis pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and LUAD, show the opposite pattern, with higher activity associated with better survival.

HNSC, CHOL, and THCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.844	0.705	.001	80	view →
CHOL	DFS	Median	II,III,IV	0.141	0.570	<.001	39	view →
THCA	DFS	Tertile	III,IV	0.618	0.863	.002	34	view →
LUAD	OS	Quartile	III,IV	0.708	0.417	.005	25	view →
LGG	DFS	Tertile	All	0.625	0.783	<.001	21	view →
UCS	DFS	Median	IV	0.885	0.440	.015	18	view →
LIHC	OS	Quartile	All	0.858	0.731	.016	15	view →
SKCM	OS	Quartile	All	0.847	0.611	.006	14	view →
PAAD	OS	Median	II,III,IV	0.693	0.369	<.001	13	view →
ESCA	OS	Median	III,IV	0.555	0.297	.003	13	view →
BRCA	DFS	Quartile	IV	0.806	0.311	.006	8	view →
READ	OS	Median	II,III,IV	0.814	0.515	.034	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0006111–HNSC (OS)

Open the HNSC breakdown →