Acetyl-CoA biosynthetic process

Across TCGA patient cohorts, RNA activity of the Acetyl-CoA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB11FIP1P1, SNORD62B, and NADK2-AS1, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acetyl-CoA biosynthetic process activity versus RAB11FIP1P1 in THYM (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	RAB11FIP1P1 →	+1.143	+0.056	<.001	<.001	3	29
UCS	SNORD62B →	+1.869	+0.066	<.001	<.001	3	29
ESCA	NADK2-AS1 →	+0.862	+0.064	<.001	<.001	2	30
SARC	NPTN-IT1 →	+1.028	+0.045	<.001	<.001	3	29
THYM	CICP14 →	+1.612	+0.053	<.001	<.001	3	29
DLBC	PDK4 →	+2.074	+0.040	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006085 vs RAB11FIP1P1 — THYM

Explore this scatter interactively →