Acetyl-CoA biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Acetyl-CoA biosynthetic process pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 18 member genes.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher Acetyl-CoA biosynthetic process pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and PAAD, show the opposite pattern, with higher activity associated with better survival.

LUAD, UCEC, and PAAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.522	0.180	.002	56	view →
UCEC	OS	Quartile	IV	0.215	0.657	.008	40	view →
PAAD	DFS	Quartile	All	0.591	0.289	.003	22	view →
ESCA	OS	Quartile	III,IV	0.811	0.500	.008	15	view →
SARC	OS	Tertile	All	0.603	0.414	.004	11	view →
OV	OS	Quartile	III,IV	0.602	0.728	.022	10	view →
LIHC	DFS	Tertile	III,IV	0.684	0.311	.010	10	view →
BRCA	DFS	Median	III,IV	0.922	0.833	.010	9	view →
THCA	DFS	Tertile	II,III,IV	0.884	0.675	.031	8	view →
LUSC	OS	Quartile	All	0.831	0.701	.009	8	view →
STAD	DFS	Tertile	All	0.501	0.604	.039	7	view →
BLCA	DFS	Tertile	IV	0.340	0.529	.011	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0006085–LUAD (DFS)

Open the LUAD breakdown →