Ethanol catabolic process

Across TCGA patient cohorts, RNA activity of the Ethanol catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SURF6, WDR5, and DDX31, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ethanol catabolic process activity versus SURF6 in GBM (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SURF6 →	-0.270	-0.235	.001	<.001	3	5
PDAC	WDR5 →	-0.218	-0.133	.005	.006	3	5
LSCC	DDX31 →	-0.476	-0.175	.002	<.001	3	5
LSCC	PAMR1 →	+0.900	+0.157	<.001	<.001	3	5
GBM	THAP8 →	-0.260	-0.193	<.001	<.001	3	5
LSCC	GTF3C4 →	-0.320	-0.109	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006068 vs SURF6 — GBM

Explore this scatter interactively →