Q-omics provides the consensus-scored THAP8 profile across patient tissues and cancer cell-line models. THAP8 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, THAP8 is differentially expressed in 11, with the highest sampling consensus in KIRC. Additionally, THAP8 RNA expression shows 19,001 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight UVM, KIRC, and ACC as cancer lineages where THAP8 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for THAP8 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes THAP8 survival associations across molecular data types. THAP8 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible THAP8 RNA expression–survival associations across cancer types. High THAP8 expression shows unfavorable associations in UVM, KICH, LIHC, UCEC, SKCM and KIRC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for THAP8 RNA expression.
This table summarizes THAP8 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for THAP8. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. THAP8 shows lower tumor expression in KICH and higher tumor expression in KIRC, HNSC, LUAD, LIHC and THCA. The KIRC box plot shows higher THAP8 RNA expression in tumor versus normal tissue (log2 FC = +0.569, t-test p < 0.001).
This table shows molecular features associated with THAP8 in patient tissues and cancer cell lines. In patient samples, THAP8 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, THAP8 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Lymphoma and LUNG_SCLC.
