Mannose metabolic process

Across TCGA patient cohorts, RNA activity of the Mannose metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PMM1, CEP170_S1079, and AKAP13_S2563, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mannose metabolic process activity versus PMM1 in LUAD (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PMM1 →	+0.294	+0.049	<.001	<.001	3	5
LUAD	CEP170_S1079 →	-0.697	-0.044	<.001	.001	3	5
PDAC	AKAP13_S2563 →	+0.200	+0.020	.009	.008	2	6
OV	IQGAP2_S16 →	+0.652	+0.046	.003	.002	3	5
BRCA	PDXDC1 →	+0.373	+0.029	<.001	.003	3	5
OV	PMM2 →	+0.555	+0.045	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006013 vs PMM1 — LUAD

Explore this scatter interactively →