Mannose metabolic process

Across TCGA patient cohorts, RNA activity of the Mannose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MOAP1, SETP6, and MTBP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mannose metabolic process activity versus MOAP1 in UCEC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MOAP1 →	+0.663	+0.138	.009	.006	2	5
GBM	SETP6 →	-0.552	-1.122	.004	<.001	3	4
BRCA	MTBP →	-0.465	-0.087	<.001	<.001	3	4
BRCA	CA12 →	+1.899	+0.105	<.001	.002	3	3
BRCA	LRRC31 →	+1.446	+0.146	.001	<.001	3	3
GBM	YWHAQP4 →	+0.960	+0.809	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006013 vs MOAP1 — UCEC

Explore this scatter interactively →