Mannose metabolic process

Across TCGA cell cohorts, RNA activity of the Mannose metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XK, OVOL2, and TET3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, XK grouped by Mannose metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	XK →	+0.238	+0.254	.002	.009	3	4
SOFT_TISSUE	OVOL2 →	+0.298	+0.188	.001	.003	3	3
SKIN	TET3 →	+0.154	+0.283	.005	.006	2	4
CNS	TRIM8 →	-0.391	-0.415	.006	<.001	3	3
LUNG_NSCLC_LUSC	EIF4A1 →	-0.336	-0.600	.008	.001	3	3
KIDNEY	PSMD4 →	+0.441	+0.331	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XK by Mannose metabolic process activity — CNS

Explore this box plot interactively →