Epithelial cell morphogenesis

Across TCGA cell cohorts, RNA activity of the Epithelial cell morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN7, EPCAM, and CLPP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell morphogenesis activity versus CLDN7 in PANCREAS (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CLDN7 →	+3.847	+1.602	.005	<.001	3	7
OVARY	EPCAM →	+3.893	+1.511	.003	<.001	3	6
LUNG_NSCLC_LUAD	CLPP →	-0.441	-0.838	<.001	<.001	3	6
LUNG_NSCLC_LUAD	CNKSR1 →	+1.587	+1.029	<.001	<.001	3	6
OVARY	EPHA1 →	+2.571	+1.450	<.001	<.001	3	6
PANCREAS	PCDH1 →	+3.205	+1.403	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003382 vs CLDN7 — PANCREAS

Explore this scatter interactively →