Cardiac neural crest cell migration involved in outflow tract morphogenesis

Across TCGA cell cohorts, RNA activity of the Cardiac neural crest cell migration involved in outflow tract morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLG4, MAP3K12, and SNRPF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DLG4 grouped by Cardiac neural crest cell migration involved in outflow tract morphogenesis-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DLG4 →	+1.738	+0.923	<.001	.004	3	5
PANCREAS	MAP3K12 →	+0.978	+0.886	.004	.008	3	4
LUNG_NSCLC_LUSC	SNRPF →	-0.673	-0.787	.002	.003	3	4
LARGE_INTESTINE	ATP8B3 →	+0.931	+1.226	<.001	.005	3	4
LARGE_INTESTINE	FABP1 →	-5.017	-1.394	.001	<.001	3	4
LIVER	PLXNB1 →	-2.030	-1.359	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DLG4 by Cardiac neural crest cell migration involved in outflow tract morphogenesis activity — PANCREAS

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