Cardiac neural crest cell migration involved in outflow tract morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Cardiac neural crest cell migration involved in outflow tract morphogenesis pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Cardiac neural crest cell migration involved in outflow tract morphogenesis pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and LIHC, show the opposite pattern, with higher activity associated with better survival.

UVM, SKCM, and READ are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.807	0.427	<.001	83	view →
SKCM	DFS	Quartile	III,IV	0.439	0.785	.002	32	view →
READ	DFS	Tertile	IV	0.394	1.000	.001	26	view →
LIHC	DFS	Quartile	II,III,IV	0.324	0.099	.002	24	view →
ACC	DFS	Tertile	III,IV	0.965	0.289	.006	20	view →
KIRC	DFS	Tertile	All	0.873	0.744	.014	18	view →
ESCA	DFS	Quartile	II,III,IV	0.561	0.362	.015	15	view →
COAD	DFS	Tertile	II,III,IV	0.627	0.773	.013	12	view →
THCA	OS	Quartile	All	0.859	0.980	.010	11	view →
STAD	DFS	Quartile	IV	0.087	0.440	.017	9	view →
KIRP	DFS	Median	IV	0.041	0.621	.019	8	view →
LUAD	DFS	Tertile	IV	0.648	0.270	.031	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0003253–UVM (OS)

Open the UVM breakdown →