Atrioventricular valve development

Across TCGA patient cohorts, RNA activity of the Atrioventricular valve development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDGFRL, VCAN, and MPDZ, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrioventricular valve development activity versus PDGFRL in OV (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PDGFRL →	+1.301	+0.267	<.001	.001	3	5
OV	VCAN →	+1.322	+0.199	.009	.008	3	5
LSCC	MPDZ →	+0.659	+0.279	<.001	.002	3	5
BRCA	RASGRF2 →	+0.673	+0.285	<.001	.006	3	5
LSCC	VGLL3 →	+0.827	+0.357	<.001	<.001	3	5
BRCA	TGFB2 →	+0.982	+0.277	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003171 vs PDGFRL — OV

Explore this scatter interactively →