Cardiac conduction system development

Across TCGA patient cohorts, RNA activity of the Cardiac conduction system development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAND1, TBX3, and ANKRD50, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac conduction system development activity versus CAND1 in LUAD (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CAND1 →	+0.394	+0.343	.001	<.001	3	4
BRCA	TBX3 →	+1.093	+0.360	<.001	<.001	3	4
LSCC	ANKRD50 →	+0.722	+0.854	<.001	<.001	3	4
HNSC	GJA1 →	+1.198	+0.918	<.001	<.001	3	4
LSCC	GOLIM4 →	+0.628	+0.669	.001	.007	3	4
GBM	COL4A5 →	+1.481	+0.911	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003161 vs CAND1 — LUAD

Explore this scatter interactively →