Cardiac conduction system development

Across TCGA pan-cancer cohorts, RNA activity of the Cardiac conduction system development pathway differs between tumor and matched normal tissue in 9 of the 18 cancer types tested.

The strongest signal is observed in kidney chromophobe (KICH), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and LUAD, show the opposite pattern, with lower activity in tumor tissue.

KICH, LUAD, and BLCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KICH	Male	All	−0.083	<.001	11	view →
LUAD	Female	All	−0.062	<.001	9	view →
BLCA	All	III,IV	−0.040	.002	9	view →
LUSC	Female	All	−0.050	<.001	7	view →
HNSC	All	All	+0.024	.001	7	view →
BRCA	All	All	−0.033	<.001	6	view →
STAD	Male	III,IV	+0.051	.004	4	view →
KIRP	All	All	−0.024	<.001	2	view →
LIHC	All	II,III,IV	+0.020	.012	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 9 strongest of 9 lineages.

GO:0003161–KICH

Open the KICH breakdown →