Cardiac conduction system development

Across TCGA pan-cancer cohorts, RNA activity of the Cardiac conduction system development pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 37 member genes.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher Cardiac conduction system development pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and LGG, show the opposite pattern, with higher activity associated with better survival.

COAD, UCS, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	IV	0.307	0.592	<.001	56	view →
UCS	OS	Quartile	II,III,IV	0.706	0.160	.003	54	view →
KIRP	OS	Median	All	0.512	0.797	.002	29	view →
LGG	OS	Tertile	All	0.875	0.728	<.001	28	view →
ACC	DFS	Quartile	All	0.845	0.189	.004	23	view →
MESO	OS	Median	II,III,IV	0.482	0.645	.018	20	view →
UCEC	OS	Tertile	II,III,IV	0.910	0.793	.005	20	view →
READ	DFS	Tertile	IV	0.152	0.739	<.001	18	view →
UVM	OS	Median	III,IV	0.304	1.000	.008	15	view →
LUAD	OS	Quartile	All	0.650	0.276	.006	14	view →
KIRC	OS	Median	All	0.914	0.853	.003	13	view →
GBM	DFS	Median	All	0.387	0.213	.025	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0003161–COAD (DFS)

Open the COAD breakdown →