Cardiac conduction system development

Across TCGA patient cohorts, RNA activity of the Cardiac conduction system development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GJA1_T275, GJA1, and GJA1_S251, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac conduction system development activity versus GJA1_T275 in LSCC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GJA1_T275 →	+1.767	+1.429	<.001	<.001	3	4
GBM	GJA1 →	+0.844	+1.485	<.001	<.001	3	4
GBM	GJA1_S251 →	+1.194	+1.209	<.001	<.001	3	4
GBM	CST3 →	+0.582	+0.984	<.001	<.001	3	3
BRCA	SAMD14_S77 →	+0.678	+0.627	<.001	<.001	3	3
HNSC	DSC2 →	+0.678	+0.642	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003161 vs GJA1_T275 — LSCC

Explore this scatter interactively →