Cardiac conduction system development

Across TCGA cell cohorts, RNA activity of the Cardiac conduction system development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL7A, MCMBP, and TBC1D2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCL7A grouped by Cardiac conduction system development-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	BCL7A →	+1.107	+1.443	.002	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	MCMBP →	+1.134	+1.428	<.001	<.001	3	5
URINARY_TRACT	TBC1D2B →	+1.224	+1.853	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	COQ9 →	+1.062	+1.375	.008	.002	3	4
UPPER_AERODIGESTIVE_TRACT	TRUB1 →	+0.853	+1.394	.001	<.001	3	4
STOMACH	YEATS4 →	+0.588	+0.904	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCL7A by Cardiac conduction system development activity — OESOPHAGUS

Explore this box plot interactively →