Heart morphogenesis

Across TCGA cell cohorts, RNA activity of the Heart morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COG7, EIF3G, and TGFBI, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COG7 grouped by Heart morphogenesis-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	COG7 →	+1.240	+0.394	.005	.001	3	4
PANCREAS	EIF3G →	-0.697	-0.158	.001	.001	3	3
LIVER	TGFBI →	-4.241	-0.188	.001	.005	2	4
KIDNEY	ULK3 →	+0.928	+0.979	.004	.003	3	3
KIDNEY	PGAP2 →	+0.621	+0.769	<.001	.005	3	3
KIDNEY	UFSP1 →	+0.793	+0.817	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COG7 by Heart morphogenesis activity — URINARY_TRACT

Explore this box plot interactively →