Heart morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Heart morphogenesis pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 261 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Heart morphogenesis pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and BRCA, show the opposite pattern, with higher activity associated with better survival.

KIRP, MESO, and ESCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.450	0.817	<.001	101	view →
MESO	OS	Median	All	0.445	0.635	.003	33	view →
ESCA	OS	Tertile	III,IV	0.805	0.347	.003	32	view →
THCA	OS	Median	II,III,IV	0.954	0.993	.001	29	view →
BRCA	OS	Median	III,IV	0.949	0.864	.017	21	view →
UCS	DFS	Quartile	II,III,IV	0.586	0.111	.010	18	view →
HNSC	DFS	Median	IV	0.384	0.267	.004	15	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	15	view →
UCEC	DFS	Quartile	IV	0.966	0.615	.008	14	view →
READ	DFS	Tertile	IV	0.189	0.671	.001	12	view →
LGG	DFS	Median	All	0.782	0.857	.004	12	view →
THYM	DFS	Median	II,III,IV	0.939	0.576	.022	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0003007–KIRP (OS)

Open the KIRP breakdown →