Response to ischemia

Across TCGA patient cohorts, RNA activity of the Response to ischemia pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are POLR1E, EFEMP1, and SF3B1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ischemia activity versus POLR1E in BRCA (Pearson r = -0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	POLR1E →	-0.456	-0.031	<.001	<.001	3	9
PDAC	EFEMP1 →	+0.592	+0.030	<.001	<.001	3	8
GBM	SF3B1 →	-0.218	-0.047	<.001	<.001	3	8
LSCC	U2SURP →	-0.261	-0.050	<.001	<.001	3	8
OV	SERBP1 →	-0.236	-0.030	.008	.004	2	8
LSCC	TRMT6 →	-0.367	-0.051	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002931 vs POLR1E — BRCA

Explore this scatter interactively →