Response to ischemia

Across TCGA cell cohorts, RNA activity of the Response to ischemia pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MANSC1, RPS15, and C19orf25, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MANSC1 grouped by Response to ischemia-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MANSC1 →	+1.618	+0.962	.004	.005	3	3
LUNG_NSCLC_LUAD	RPS15 →	-0.418	-0.465	.004	.006	3	3
LUNG_NSCLC_LUAD	C19orf25 →	-0.673	-0.482	<.001	.002	3	3
LUNG_NSCLC_LUAD	MTMR2 →	+0.415	+0.349	.004	.002	3	3
SKIN	KLHL29 →	-0.794	-0.857	.001	<.001	3	3
SKIN	ENDOD1 →	-0.897	-0.820	.008	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MANSC1 by Response to ischemia activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →