Response to ischemia

Across TCGA cell cohorts, RNA activity of the Response to ischemia pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APAF1, FDX1, and DOCK5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ischemia activity versus APAF1 in BLOOD_Leukemia (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	APAF1 →	-0.741	-0.206	.003	<.001	3	5
URINARY_TRACT	FDX1 →	-0.882	-0.475	.006	.006	3	5
CNS	DOCK5 →	-2.422	-0.278	.005	.007	3	4
PANCREAS	IL15 →	+1.351	+0.261	<.001	.007	3	4
LARGE_INTESTINE	CAST →	-1.110	-0.159	<.001	<.001	3	4
OVARY	GJC1 →	-1.895	-0.356	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002931 vs APAF1 — BLOOD_Leukemia

Explore this scatter interactively →