Response to ischemia

Across TCGA cell cohorts, RNA activity of the Response to ischemia pathway is significantly associated with the protein abundance of multiple proteins, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPIF, TUBA4B, and ATP5IF1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ischemia activity versus PPIF in OESOPHAGUS (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PPIF →	+1.556	+0.392	<.001	<.001	3	14
CNS	TUBA4B →	-1.032	-0.203	<.001	<.001	3	10
BLOOD_Myeloma	ATP5IF1 →	+1.337	+0.272	<.001	<.001	3	10
PANCREAS	EML6 →	-1.253	-0.220	.002	.002	3	9
KIDNEY	STOML2 →	+1.064	+0.276	.004	.006	3	9
CNS	PAM16 →	+0.549	+0.184	.006	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002931 vs PPIF — OESOPHAGUS

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