Negative regulation of type 2 immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of type 2 immune response pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C8orf76, MIR1915HG, and GRAMD4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C8orf76 grouped by Negative regulation of type 2 immune response-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	C8orf76 →	-0.398	-0.793	.001	.007	3	4
OVARY	MIR1915HG →	-1.284	-1.006	<.001	<.001	3	4
BLOOD_Lymphoma	GRAMD4 →	+2.110	+1.375	.009	.001	3	4
BLOOD_Leukemia	TMOD4 →	-0.352	-0.780	.004	.009	2	5
LIVER	MROH6 →	-1.323	-1.405	<.001	.007	3	4
SOFT_TISSUE	PMAIP1 →	-3.064	-0.737	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C8orf76 by Negative regulation of type 2 immune response activity — CNS

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