Negative regulation of type 2 immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of type 2 immune response pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCIF1, CCT7, and KATNAL2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCIF1 grouped by Negative regulation of type 2 immune response-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PCIF1 →	-0.485	-1.848	.006	.008	1	2
BREAST	CCT7 →	+0.915	+1.848	.008	.008	1	2
BREAST	KATNAL2 →	+0.114	+1.848	.001	.008	1	2
BREAST	COL8A2 →	-0.150	-1.848	.008	.008	1	2
BREAST	PPP6R2 →	-0.200	-1.848	.001	.008	1	1
BREAST	PSMD7 →	-0.390	-1.848	.008	.008	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCIF1 by Negative regulation of type 2 immune response activity — BREAST

Explore this box plot interactively →