Negative regulation of myeloid leukocyte differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of myeloid leukocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MET, COX8A, and TRIM59, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MET grouped by Negative regulation of myeloid leukocyte differentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MET →	-1.770	-0.444	.002	.009	3	4
OESOPHAGUS	COX8A →	-0.791	-0.287	.005	.004	3	3
STOMACH	TRIM59 →	-2.040	-0.392	<.001	.002	3	3
BLOOD_Lymphoma	ZFC3H1 →	+0.723	+0.372	.002	.003	2	4
CNS	NXNL2 →	-0.583	-0.701	.006	.003	3	3
OESOPHAGUS	RBM3 →	-1.221	-0.271	.009	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MET by Negative regulation of myeloid leukocyte differentiation activity — OVARY

Explore this box plot interactively →