cytochrome c oxidase subunit 8AGenealiases: COX · COX8 · COX8-2 · COX8L · MC4DN15 · VIII
Q-omics provides the consensus-scored COX8A profile across patient tissues and cancer cell-line models. COX8A expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, COX8A is differentially expressed in 12, with the highest sampling consensus in LIHC. Additionally, COX8A RNA expression shows 19,996 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight ACC, LIHC, and THYM as cancer lineages where COX8A shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for COX8A — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes COX8A survival associations across molecular data types. COX8A RNA expression shows survival associations in the most cancer types (27). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible COX8A RNA expression–survival associations across cancer types. High COX8A expression shows unfavorable associations in ACC, HNSC, LUAD, LIHC and UVM, but favorable associations in OV. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for COX8A RNA expression.
This table summarizes COX8A tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for COX8A. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. COX8A shows lower tumor expression in COAD and THCA and higher tumor expression in LIHC, LUSC, BLCA and BRCA. The LIHC box plot shows higher COX8A RNA expression in tumor versus normal tissue (log2 FC = +1.059, t-test p < 0.001).
This table shows molecular features associated with COX8A in patient tissues and cancer cell lines. In patient samples, COX8A shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, COX8A RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and UPPER_AERODIGESTIVE_TRACT.
