COX8A

Across TCGA patient cohorts, COX8A mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COX8A-associated genes across cancer lineages are OOEPP1, MIR548D2, and RNU6-508P. Each is linked with COX8A in more than 1 cancer types. Because this analysis shows association rather than direction, both COX8A-to-partner and partner-to-COX8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OOEPP1 grouped by COX8A-low versus COX8A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX8A→partner) and Y-score (partner→COX8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OOEPP1 →	+0.569	+4.690	<.001	.003	3	1
UCEC	MIR548D2 →	+0.623	+4.694	<.001	.007	3	1
UCEC	RNU6-508P →	+0.732	+5.453	<.001	.002	3	1
UCEC	GYG2P1 →	+0.088	+4.233	<.001	.009	3	1
UCEC	RNU6-1292P →	+0.829	+5.453	<.001	.002	3	1
UCEC	TRBV5-3 →	+0.267	+4.256	.008	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

OOEPP1 by COX8A expression — UCEC

Explore this box plot interactively →