Negative regulation of myeloid leukocyte differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of myeloid leukocyte differentiation pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 53 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher Negative regulation of myeloid leukocyte differentiation pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and HNSC, show the opposite pattern, with higher activity associated with better survival.

SKCM, LGG, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.417	0.279	<.001	85	view →
LGG	DFS	Quartile	All	0.601	0.841	<.001	43	view →
HNSC	DFS	Median	III,IV	0.748	0.617	.004	35	view →
GBM	DFS	Tertile	All	0.157	0.294	.002	24	view →
LUSC	DFS	Median	II,III,IV	0.285	0.480	.001	24	view →
STAD	OS	Median	All	0.422	0.633	.018	23	view →
BRCA	DFS	Median	III,IV	0.560	0.412	.006	23	view →
THYM	OS	Tertile	II,III,IV	0.846	1.000	.003	21	view →
KIRC	DFS	Quartile	All	0.736	0.820	.011	15	view →
MESO	OS	Tertile	All	0.216	0.410	.030	11	view →
UVM	DFS	Quartile	All	0.579	0.912	.024	11	view →
SCLC	OS	Median	IV	0.201	0.772	.024	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0002762–SKCM (OS)

Open the SKCM breakdown →