Glandular epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Glandular epithelial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINA7, SLIT3, and CNRIP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glandular epithelial cell differentiation activity versus SERPINA7 in BRCA (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERPINA7 →	+0.597	+0.023	.001	.006	3	6
BRCA	SLIT3 →	+0.350	+0.025	<.001	<.001	3	6
BRCA	CNRIP1 →	+0.699	+0.031	<.001	<.001	3	6
CCRCC	HSPA12B →	+0.428	+0.048	<.001	<.001	3	6
UCEC	JPT1 →	-0.356	-0.039	.003	.008	3	6
OV	A1BG →	+0.528	+0.037	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002067 vs SERPINA7 — BRCA

Explore this scatter interactively →