Glandular epithelial cell differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Glandular epithelial cell differentiation pathway differs between tumor and matched normal tissue in 10 of the 18 cancer types tested.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as UCEC and KICH, show the opposite pattern, with lower activity in tumor tissue.

UCEC, KICH, and LUAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
UCEC	All	II,III,IV	−0.055	<.001	8	view →
KICH	Male	All	−0.082	<.001	7	view →
LUAD	Female	II,III,IV	−0.034	<.001	7	view →
BRCA	All	III,IV	−0.060	<.001	6	view →
LIHC	Female	All	+0.030	<.001	6	view →
HNSC	All	II,III,IV	−0.022	.001	6	view →
KIRC	All	II,III,IV	−0.012	.006	5	view →
LUSC	All	All	−0.022	<.001	4	view →
THCA	All	All	−0.012	.026	3	view →
CHOL	Male	All	+0.063	<.001	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 10 strongest of 10 lineages.

GO:0002067–UCEC

Open the UCEC breakdown →