Glandular epithelial cell differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Glandular epithelial cell differentiation pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 71 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Glandular epithelial cell differentiation pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and BRCA, show the opposite pattern, with higher activity associated with better survival.

HNSC, MESO, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.512	0.253	<.001	57	view →
MESO	OS	Quartile	II,III,IV	0.242	0.454	.012	45	view →
BRCA	OS	Median	All	0.951	0.903	.001	44	view →
LIHC	OS	Quartile	All	0.562	0.831	<.001	39	view →
UVM	OS	Tertile	II,III,IV	0.707	0.363	.006	39	view →
ACC	DFS	Median	IV	0.142	0.501	.003	36	view →
UCS	DFS	Tertile	IV	0.978	0.239	.024	24	view →
THCA	DFS	Median	IV	1.000	0.551	.004	20	view →
LAML	DFS	Tertile	All	0.193	0.614	.001	12	view →
CESC	DFS	Quartile	All	0.686	0.871	.004	12	view →
LUAD	OS	Median	IV	0.337	0.756	.021	12	view →
READ	DFS	Median	IV	0.316	0.731	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0002067–HNSC (DFS)

Open the HNSC breakdown →