Glandular epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Glandular epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOBEC3G, SMYD2, and IPO9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APOBEC3G grouped by Glandular epithelial cell differentiation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	APOBEC3G →	+2.985	+1.789	.002	.002	3	4
SKIN	SMYD2 →	+0.513	+0.965	.002	<.001	3	4
SKIN	IPO9 →	+0.790	+1.059	.003	.006	3	4
LARGE_INTESTINE	ZC3H7B →	+0.776	+1.309	.003	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	RPL11 →	-0.902	-1.156	<.001	.001	3	3
LUNG_SCLC	PFDN6 →	-0.591	-1.432	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APOBEC3G by Glandular epithelial cell differentiation activity — SOFT_TISSUE

Explore this box plot interactively →