Fatty acid alpha-oxidation

Across TCGA patient cohorts, RNA activity of the Fatty acid alpha-oxidation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABITRAM, HACL1, and KIF5B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid alpha-oxidation activity versus ABITRAM in BRCA (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ABITRAM →	+0.424	+0.210	<.001	.001	3	4
BRCA	HACL1 →	+0.257	+0.129	.008	.006	3	3
BRCA	KIF5B →	+0.459	+0.242	<.001	.001	3	3
LUAD	RNF152P1 →	+0.625	+0.112	<.001	.004	3	3
GBM	TUBG1 →	+0.374	+0.094	<.001	<.001	3	3
GBM	FARSA →	+0.244	+0.101	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001561 vs ABITRAM — BRCA

Explore this scatter interactively →