DNA synthesis involved in DNA repair

Across TCGA patient cohorts, RNA activity of the DNA synthesis involved in DNA repair pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, SMC4, and TOP2A, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA synthesis involved in DNA repair activity versus SMC2 in GBM (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC2 →	+0.539	+0.047	<.001	<.001	3	9
OV	SMC4 →	+0.536	+0.045	<.001	<.001	3	9
LUAD	TOP2A →	+0.828	+0.052	<.001	<.001	3	9
OV	LIG1 →	+0.427	+0.049	<.001	<.001	2	10
LUAD	MCM3 →	+0.669	+0.048	<.001	<.001	3	9
LUAD	MCM7 →	+0.654	+0.050	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000731 vs SMC2 — GBM

Explore this scatter interactively →