Maturation of 5.8S rRNA

Across TCGA cell cohorts, RNA activity of the Maturation of 5.8S rRNA pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGAP3, SCP2, and BCL6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maturation of 5.8S rRNA activity versus PGAP3 in BREAST (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PGAP3 →	-2.225	-0.187	.002	.009	3	8
LUNG_NSCLC_LUSC	SCP2 →	-1.347	-0.448	.008	.006	2	8
UPPER_AERODIGESTIVE_TRACT	BCL6 →	-1.838	-0.428	.007	.001	3	7
LUNG_SCLC	RNF19A →	-1.384	-0.296	<.001	.001	3	6
BREAST	MLPH →	-2.200	-0.229	.003	.002	3	6
BLOOD_Leukemia	TAMM41 →	+0.572	+0.172	.002	.005	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000460 vs PGAP3 — BREAST

Explore this scatter interactively →