Maturation of 5.8S rRNA

Across TCGA pan-cancer cohorts, RNA activity of the Maturation of 5.8S rRNA pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 36 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Maturation of 5.8S rRNA pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and UCS, show the opposite pattern, with higher activity associated with better survival.

KIRC, LIHC, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	II,III,IV	0.414	0.622	<.001	131	view →
LIHC	OS	Tertile	All	0.670	0.830	<.001	75	view →
ACC	OS	Tertile	All	0.647	0.953	<.001	64	view →
READ	OS	Median	All	0.915	0.456	<.001	57	view →
UCS	DFS	Median	II,III,IV	0.546	0.154	.003	36	view →
KICH	DFS	Quartile	All	0.416	0.918	.001	36	view →
LGG	DFS	Median	All	0.760	0.879	<.001	33	view →
STAD	OS	Quartile	III,IV	0.385	0.660	.004	28	view →
UVM	DFS	Median	III,IV	0.305	0.708	.002	19	view →
KIRP	DFS	Median	All	0.475	0.676	.003	17	view →
SKCM	DFS	Tertile	IV	0.680	0.079	.009	15	view →
HNSC	OS	Median	IV	0.476	0.335	.008	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0000460–KIRC (OS)

Open the KIRC breakdown →