Protein deneddylation

Across TCGA patient cohorts, RNA activity of the Protein deneddylation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RN7SKP16, RCOR1, and TTC36, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein deneddylation activity versus RN7SKP16 in COAD (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SKP16 →	+0.541	+0.104	.003	<.001	3	4
LUAD	RCOR1 →	+0.287	+0.081	.004	.006	3	4
CCRCC	TTC36 →	-0.412	-0.110	.001	.001	3	4
LSCC	SLC3A1 →	-0.159	-0.111	.001	<.001	3	4
COAD	BCL6 →	+0.733	+0.093	.002	.005	3	3
LUAD	MOGAT1 →	-0.311	-0.103	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000338 vs RN7SKP16 — COAD

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