Protein deneddylation

Across TCGA patient cohorts, RNA activity of the Protein deneddylation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GPS1_S474, SHANK3_S775, and STAG2_S1061, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein deneddylation activity versus GPS1_S474 in PDAC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	GPS1_S474 →	+0.634	+0.157	.001	<.001	3	4
LSCC	SHANK3_S775 →	-0.997	-0.133	<.001	<.001	3	3
OV	STAG2_S1061 →	+0.534	+0.094	.006	.005	1	5
OV	ERC1_S37 →	-1.616	-0.109	<.001	<.001	3	3
OV	HCFC1_S598 →	+0.446	+0.077	<.001	<.001	3	3
PDAC	OSBPL8_S808 →	+0.513	+0.110	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000338 vs GPS1_S474 — PDAC

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